SQUAMOUS LESIONS BEFORE CANCER

Accompanied by major changes in the bronchial mucosa leading to the invasion or
Squamous cell carcinoma, inflation, squamous metaplasia, squamous cell carcinoma has a
Dysplasia and CIS (128,129). The lesions can vary from squamous dysplasia
Severity (ie mild, moderate and severe), but these lesions
You kept unusual changes in cells and tissues
The classification reflects the overlap. Little, for speed and risk, little is known
And finally the development of invasive squamous dysplasia to CIS
Squamous cells.
The current business model of sequential molecular abnormalities
Cause of lung cancer, squamous cell carcinoma (Figure 1) shows the abnormal gene.
Begin to rise with a histologically normal epithelium increased
The severity of histological changes (130). Mutation, according to the sequence
Allelic loss at multiple sites of 3P progressive chromosome (3p21, 3p14, 3p22 - 24,
And 3p12) and 9p21 (p16INK4A), and changes in the nearest time to detect. Subsequent changes
23.13 Q14 (RB), 17p13, and (TP53) (15,113,130) - Contains the 8p21. Methylation of p16INK4A
In addition, increasing the frequency during the evolution of the disease of the organization, which is detected early, before the invasion of squamous lesions (24%
Squamous metaplasia and 50% CIS) (131). Molecular changes in the airways
Through extensive airway epithelium of smokers and
Patients with lung cancer, and yes, the field effect ("field cancerization") suggests that the
Mutations in a wide range of respiratory epithelium, probably
Tobacco-related risks (15.130132133) carcinogen. Use of fluorescent
Bronchitis can be a lot of points and molecular cloning subclonal
Abnormalities, including genetic instability and loss of alleles. These points
By setting (consisting of the estimated 40,000 ~ 360,000 of normal) can be detected.
Normal and abnormal bronchial epithelium of lung cancer patients slightly
(134). This progress, despite the changes in molecular characteristics and fiber
It proved useful for the prediction of precursor lesions of squamous cell carcinoma
Invasive cancer (9135) develop.