MICROENVIRONMENT OF THE TUMOR

Genetic changes, which are important for malignant transformation,
In addition, epithelial cells and micro cells that can be applied to cancer.
Most tumors are characterized by a cellular microenvironment that occur in
Host immune dysregulation and inflammation, and inhibiting the production of growth
Stimulates vascular cell survival, growth factors to prevent
Apoptosis. According to a study highlighted in this chapter, lung volume
Microenvironment in the reaction media and through the process of carcinogenesis.
Understanding the molecular mechanisms involved in volume per
For small lung carcinogenesis, we offer you the opportunity to develop
Which is reflected in the drug prevention and nonmutational purpose of these events
Treatment of lung cancer. Recent results of clinical microbiology-related
The significance of lung cancer research immunopathobiology understand
Surgical treatment targeted assistance, planning assistance and future experiments
Treatment. Field, as the promise of progress and the cause of the laboratory
Be translated into treatments for cancer and testing for the future of the tumor microenvironment
They should also improve the risk assessment and patient selection
Continuous evaluation of the optimal use of combination therapy away
Testing the biological dose for each connection. Targeted tumor
Microenvironment of the number of patients is highly selected for the new emerging
Strategy has a unique element to progress at this stage of lung cancer
Prevention and treatment.
Genetic variation is important for malignant transformation of epithelial
Cells, cells of microorganisms in the right and carcinogenesis.
Most tumors occur in the microenvironment of the cell suppression
Host immune dysregulation and inflammation, and increased production of mobile phones
Survival and growth factors that stimulate blood vessels and prevent apoptosis. And
Lung microenvironment, in particular, is a unique center
Lung carcinogenesis proceeds of collusion with the matrix (the structure of the extracellular
Or ECM), soluble (cytokines, proteases, hormones, etc.) and cellular (fibroblasts,
Inflammatory cells, endothelial cells, and so on. ) Micro components.
Understanding the molecular mechanisms involved in volume per
For small lung carcinogenesis, we offer you the opportunity to develop
Which is reflected in the drug prevention and nonmutational purpose of these events
Treatment of lung cancer.
In recent years, the study of gene expression profiles of different types
Description of the molecular signatures associated with progress. Identification of strengths
Biomarkers that can predict the onset of cancer, the diagnosis was clinically
Managing non-small cell lung cancer (NSCLC) cancer affects such a large
And vital signs can help you right patients benefit from
Surgery and subsequent treatment. Molecular signatures
This group is composed of genes that form the basis of cytokine genes are associated with
Involved in inflammation and immune responses. Such studies Bhattacharjee
In 2001, colleagues, microarray-based expression profiling of 139 detached
Adenocarcinoma specimens, the researchers were able to distinguish
Not only a subset of biologically different adenocarcinoma, primary lung adenocarcinoma
Nonlung metastases have been established for (1). And gene expression profiles
Closely followed in the investigation and beer. (2). This group uses the equation
Profiling to predict survival in patients with early lung cancer with adenocarcinoma.
Using 50 genes that were differentially expressed, the researchers developed
Survival based on the risk index has been identified as high risk patients or
Lower risk of adenocarcinoma] I am good and bad staging, or the expectation of survival, respectively,
Based on molecular signatures. And the new genes related to survival
Been identified, more importantly, molecular profile, the predicted results
Survival of the patient population. HSA also Haimiru - 155, HSA of leftist low
7A - 2 miRNA expression signature correctly described Yanaihara et al.
He predicted the survival of patients with adenocarcinoma of the poor] I (3) steps. And
Finally, select the mRNA expression profile described by Petit and colleagues.
A high risk of relapse (4) A subgroup of patients with stage IA non-small cell lung cancer. Together, these
The study gives a first indication of the potential diagnostic expression profiling.
Evidence of a molecular signature that is composed mainly of inflammation appears
Immune-related cytokines that are associated with important clinical parameters.
Recent studies on the role of the microenvironment of the lung volume in promoting
It was conducted by Seki et al carcinogenic. (5). It is used to investigate changes in gene expression in noncancerous tissue surrounding the tumor,
Biological marker for predicting the development of cancer diagnosis and performed by this group
Study the molecular characteristics of tumors and paired non-cancerous tissue from 80
Patients with adenocarcinoma. The number of genes identified as part of a unique
Signing of the immune response and inflammation has been previously noted that the group
Patients with liver cancer (6) non-cancerous liver tissues. At the end of the day, however,
Identification of cytokine-called survival of lung adenocarcinoma and 11 gene signatures
Predicting lymph node status and disease - the gene 11 (11 classes) is signed by
For the prediction. This experiment is designed to better show the signature of the molecule
May be associated with tumor microenvironment as a key indicator of a strong
Prediction and diagnosis of cancer progression.
However, lung cancer has not been published by the farmers and their colleagues, and most recently
Outstanding contributions in the first report of drug-sensitive genes of the organization
Status of randomized clinical trials (7). For 63 tumor biopsies from individuals
Trained in the EORTC 00 〜 01 10994/BIG estrogen receptor negative breast cancer
Treatment with fluorouracil - 5, epirubicin and cyclophosphamide (FET), the farmers
He described the signing of a series of genes that are expected to resist the tonsils before surgery
Chemotherapy. In this study, we extend the clinical importance to determine
Microscopic tumor is associated with the signing of the gene, and encourage
To overcome resistance, new agents how antistromal
Chemotherapy.
In addition, the cells were identified, Kurie Translational research laboratory in 2008
Development of non-small cell lung cancer and stromal cell interactions (8).
One of the three lung adenocarcinoma cell line of the head - by co-culture mutants lung K
Then stromal cells (macrophages, endothelial cells, or fiber) and
Profiling of the secreted proteins, to make way for the evaluation of laboratory models and
Stromal cell mechanisms that regulate biological characteristics of lung cancer
These cells. The team confirmed that the summary in the form of a strong laboratory
Many features of the mutant K-models - the head of the mouse, and more importantly,
It is suggested that non-small cell lung carcinoma is a useful model for non-small cell lung cancer tumors,
Microenvironment. Two different approaches, and research with an overview of the proteins
Secretome of cells and biological evaluation of the tumor cells and tissues.
They conclude that changes in the tumor stromal cells in the tumor microenvironment
Cells that proteins required for tumor growth and proliferation of secretome.
In particular, the increased migration of stromal cells, leading to the formation of endothelial cell tube
The difference increases with the diffusion of proteins on cancer cells
Vascular inflammation in the transition, and the proliferation of epithelial cells and mediators,
When co-cultured with stromal cells, cancer cells (EMT) was observed for all.
These results indicate that the cell is organized by the leadership of an aggressive cancer cells
effects on cancer cells secretome. Specific inhibition of the interaction of expansion,
Between adjacent layers of cancer cells and tumors have a high potential
The search for new cancer treatments.
Cancer progression depends on the genetic changes that affect epigenetic
Tumor and the surrounding layer of gene expression, and immune-dependent
Status of the reception. The research described in this chapter together in the course of the reaction and the tumor microenvironment of lung cancer, and display media
Carcinogenesis. Targeting the tumor microenvironment suitable
The selected patients is an emerging strategy that has a unique component,
Forward in this state for the prevention of lung cancer and its treatment.