FEATURES OF SIMILAR GENETIC

The term "gene" refers to genetic changes in the patterns of gene expression
Mediated by mechanisms other significant changes in the nucleotide
Sequence of the gene (116). Contains the genetic changes in the DNA of normal
Three types of changes: chromatin modification, DNA, and genomic
Mapping, each change in cancer cells. This control
Play an important role in the successful operation of the human genome and packaging and
Diseases such as cancer (117) and developed. Epigenetic change
Is often used is usually between the epigenetic changes in human tumors and a strong alternative
Genetic diversity. In studies of genetic changes in cancer
What is the first evaluation of the DNA of the new world
Proposed epigenetic model advances. This observation is a unified public
Mechanism for the development of cancer (118).
It has been reported that tumor suppressor gene in different hypothetical and known
Inactivated by methylation in lung cancer. It is a shame. (119) conducted
Genome wide screen and a holistic approach to file expression in NSCLC cells
Identified 132 genes that caused the line is the expression of DNA demethylation
Under ¢ 5 - Aza -2 - deoxycytidine - ¢. Analysis of promoter methylation
Some of the surrounding areas and benign of these genes in primary lung tumors
Showed the tumor tissue instead of 31 genes in which methylation of the normal lung
Or peripheral blood cells. For the family. (120), and 13 positions show significant
Differences in the levels of DNA between the tumor and nontumoral lung tissue,
Showed hypermethylation is very important from lung cancer eight of them.
Has been found extensive tissue forms of the gene methylation
NSCLCs, APC methylation of RAR, CDH13 and - type B
And squamous cell carcinoma with adenocarcinoma (58) is much higher than that. This is reflected RASSF1A genes on March 1, RUNX3, and non-small cell lung cancer (121) associated with poor prognosis in patients with CDH13 surgical resection, or similar relationship RUNX3 methylation and interesting with a poor prognosis
Adenocarcinoma, while methylation was associated with RASSF1A,
Misdiagnosis in the squamous epithelium. In multivariate analysis, both genes may
Been found to predict worse outcome independent of the (121) to be.
P16Ink4 methylation, CDH13, RASSF1A, APC in the first phase of lung non-small cell cancer and tumor
Histologically negative lymph nodes of the volume associated with the recurrence of the disease,
Independent of other clinical and pathological factors (122). These results
Indicate that methylation of four genes in patients with stage I NSCLC cut
And is associated with early recurrence and therapeutic intent.