Macrophages and mast cells nearly all malignant tumors

Macrophages and mast cells is a component of the innate immune cell infiltration.
Found in nearly all malignant tumors. Basic research, translational and clinical
All of the survey, this active immune cells in particular, found
Context for the growth of the tumor microenvironment to support and dependence on the film
(9-12). On the other hand, cell invasion studies linking obesity and non-small cell lung macrophages
Under a relatively small data support the opposite view is expected to
Links to a good prognosis, the diagnosis is associated with poor support and
(13-23). A recent report showed that many of these differences can be
The difference between the number and grade, stage, due to the size of the tumor and
Study differs considerably between the studies. Lack of consensus
It is within and between different types of tumors associated with a different approach
Used to evaluate the leak. For example, Chen and his colleagues in the two versions
The density of tumor-associated macrophages that are associated with poor prognosis
NSCLC, and that of the adjacent layers of macrophages in the tumor, but
(13.14) calculated together. Tommy and his colleagues, the observed association between
As a result, it is interesting non-small cell lung macrophages, and macrophages in the tumor
From Chen, measured again in the next 23 along the waste. (13.14).
Any relationship between volume and associated strata, Johnson and colleagues found
Macrophages and NSCLC diagnosis, but semi-quantitative estimation,
The number of cases evaluated (16) is relatively small. Early research
The importance of macrophages as a microanatomical location to show
He is not the stomach, had a relationship with the diagnosis of lung cancer. Ono and colleagues
Count, especially in gastric cancer cells and macrophages
Can be found on the source / around the tumor islands, infiltration of macrophages
Increased survival (24) is attached. 5-year disease-free survival
There was a significant increase in the number of patients with large numbers of macrophages
Islands of the volume compared to a small number of macrophages in human
Isle of tumors (44% vs. 87%, respectively, p = 0.0002). In fact, the density
Were independent predictors of patient survival and tumor infiltration of macrophages
Cox multivariate analysis (P = 0.016). In combination with the booster
Staining of the data, these results have led researchers to conclude
Collections of macrophages in the tumor of the stomach, has a beneficial effect on the host
Survival increased cytotoxicity and antigen presentation.
One of the most recent study of the prognostic significance of macrophages
There was infiltration of mast cells in non-small cell lung cancer Welsh et al. (25).
Groups, such as mast cells and should be taken Ono microanatomical tumor-associated macrophages, the authors of this study show
Account by looking at the relationship with prognosis. Since the micro-
The primary determinant of immune cell function and phenotype, and this is.
It also considers that there could affect the nature of the interaction of the tumor cells of the immune system.
Used to the immune system macrophages and CD68 + + tryptasis determine
Islands adjacent to the waste of 175 cases of mast cells and tumor surgery
Work of non-small cell lung cancer, as a writer, was identified in the volume density of the island of CD68 + macrophages
It provides a strong and independent survival. In particular, increasing the volume of the island
Macrophage density (P <0.001), increasing the island of interstitial macrophages / or tumor
Tissue while increasing index (P <0.001) prognostic index is better
Decrease in the density of macrophages was an independent predictor of survival (p = 0.001), respectively.