ANGIOGENESIS INTERACTION CANCER CELLS, ENDOTHELIAL CELLS AND STROMAL CELLS

Nutrients and oxygen through the blood vessels is critical for cell survival; Therefore, angiogenesis is essential for tumor growth. Angiogenesis is the interaction Cancer cells, endothelial cells and stromal cells (61) in between. About Set endothelial inducers and inhibitors of growth factors, including Cell proliferation and migration has been identified in lung cancer. Vascular Also known as vascular permeability factor for endothelial growth factor (VEGF), an important regulator of angiogenesis (62) is referred to the high expression of VEGF, Approximately 60% of stage I NSCLCs closely associated with high intra-ogkiki
angiogenesis and poor prognosis (63). Most of the surveys in non-small cell lung cancer
High expression of VEGF, the correlation between high density micro-vascular support (MVD), and a poor prognosis (61). Other angiogenesis factors, recent research Lung cancer and its receptor, platelet-derived growth factor (64), hypoxia is Factor - 1A (65) and basic fibroblast growth factor and inducible receptor 1, 2 (66). Fibroblast growth factor 2 (FGF2) or basic FGF (bFGF) and transmembrane Tyrosine kinase receptors (FGFRs) form of the mark, a large and complex family Molecules involved in various physiological processes, and their interference Cancer development (67, 68) and related molecules. bFGF belongs. Widely expressed in the extracellular ligand binding domain of the family FGFRs, start signaling cascade that promotes cell proliferation, Motility and angiogenesis (67-69). Other pathways of angiogenesis and The bFGF pathways (66, 70 to 76), by activation of lung cancer. High
bFGF, FGFR1, FGFR2, and protein levels found in NSCLC cell Lines (66, 77). bFGF, FGFR1, FGFR2 frequently overexpressed in squamous cell Carcinoma and adenocarcinoma of the lung. bFGF activated signaling pathways In the pathogenesis of squamous cell carcinoma of the first symptoms may be chemopreventive and treatment of cancer is an attractive new target Strategy (78). Epithelial - mesenchymal transition - Develops from the epithelial cells undergo a change whereby the process Set the mesenchymal phenotype (79). This process is associated with embryonic sense Epithelial morphogenesis, fibrosis, and recent progress, and transition Tumors (80). Epithelial mesenchymal transition described in
Lung cancer (51, 81, 82), including various types of cancer. Cancers have emergency In vitro, the expression of EMT markers studied the individual Description and results of these indicators (51, 83) are related. We show Phenotype of an emergency (E - cadherin loss and N - cadherin, integrinavb6 profit vimentin, and the matrix metalloproteinase - 9) will appear as often Squamous cell carcinoma and adenocarcinoma of the lung (Prudkin others are not). The results of these studies assumed that the target for lung cancer, the paramedics are on LED Treatment of cancer. EMT phenomenon also associated with resistance Inhibitors of EGFR (51) and treatments.