ADENOCARCINOMA LESIONS

It has been suggested that adenocarcinoma in AAH before about
Seruea? (10,128), but the specific structure of the respiratory epithelium
Not known the type of cells involved in the development of the majority of lung adenocarcinoma
(Figure 1).
AAH is a precursor of adenocarcinoma (10 128) was adopted.
AAI is a real disease that occur in individual cells to a plant closing,
Bronchioles. Because of its size, AAH cells are usually random
Results of the textile industry, especially when it comes to a 0.5 cm can be given in many
Or more. Increased use of high-resolution CT to determine
The purpose of the audit, but the consciousness of the AAH, has led to
The main differential diagnosis of pests, air-filled terminal (referred to as
"Coverage of Glass"). Oh and keep the lining of rounding alveolar structure
Cubic or low columnar cells. Evolution from AAH to adenocarcinoma assume that
Using the functions of the BAC, as evidenced by an abnormal growth, more and more,.
Supported by the results of morphological studies, cytofluorometric and molecular
(10,129). AAH is still unclear origin, phenotypic modulation
Derived from the structural features indicate the presence of maternal immunity
Progenitor cells in the airways, such as type II and Clara cells, because
pneumocytes (136,137).
There is a growing body of evidence supporting the concept of AAH and
At least a subset of adenocarcinoma precursor. Several molecular changes frequently
Within the AAH lesions and adenocarcinomas of the lung,
AAI is the truth of neoplastic lesions (136) provides further evidence that can represent.
The main conclusion, the presence of a maximum of KRAS mutations (codon 12).
Of 39% aahs, and these mutations are relatively frequent changes in the lungs.
Adenocarcinoma (10 138). That overexpression of the other molecular changes found in AAH
Since cyclin D1 (~ 70%), p53 (10έως58%), survivin (48%) and HER2 catalyst
(7%), protein (10139140). Great importance, the EGFR mutations
In some cases of atypical AAH adenocarcinoma, cut the regional structures
For further evidence of the precancerous lesions are peripheral
Adenocarcinoma (54).