PROTEOMICS SIGNATURE

It is proposed that it is based proteomics approach to complete the genome
Initiative represents the next step in the attempt to understand the biology
Of cancer. MRNA expression, because they do not always correspond with protein
Expression of this gene expression analysis using cDNA does not necessarily indicate
Can be expressed in its activities and the amount of protein can be modulated post-translationally
(123). Therefore, a comprehensive analysis of protein expression in the form of organization
Improve our ability to explore the complexity of the molecular size to understand
The cells. Others in time of flight mass / matrix assisted laser desorption ionization
A glance, a protein in the tissue (124) - spectrometry (TOF MALDI MS). This technique is
Components of the tumor tissue, only the peptide or protein, but you can
You can also use high-resolution imaging of biomolecules present in the tissues of the individual
Part (124). MALDI - TOF using MS, proteomics recent data
To small amounts of frozen tumor tissue from the lungs directly, and use the precise classification of
Lymph node metastases and predict for survival and textile collections
NSCLCs (125) eradication. These data, if confirmed in larger series,
The results of the analysis to be effective, the prognosis and treatment
Patients with NSCLC. Have been developed recently by MALDI - TOF MS algorithm
Samples of blood serum, in terms of good and evil, we were able to patients non-small cell lung cancer for the classification of
EGFR TKIs (126) after treatment with the results. Thus, the algorithm
Possible role in the selection of appropriate treatment for sub-groups
Non-small cell lung cancer patients treated with molecularly targeted therapies.