REGULATORY T CELLS - THE LUNG CANCER AND OTHER MALIGNANCIES

It is often an active immune suppression has been reported to be caused by tumors of the lung
Cancer and other malignancies. In many cases, tumor-reactive T cells are accumulated in the lungs Cancer tissue tumors (36) does not respond to. Many of these CD25high cells limousine - a non-small cell lung tumor cell invasion (SESAME) is a CD4 + T. (34.35). Cancer cells can enhance immunity by guiding around Cytokine release from inflammatory cells by inhibiting the tumor microenvironment And / or enhanced T reg cells increased trade at the tumor site Active cells Limousine (32) in the differentiation of T lymphocytes. There are significant barriers Effective treatment for non-small cell lung cancer, which is our understanding of disorders of the lung. Cancer cells to avoid immune surveillance and anti-tumor immune suppression. So T - to identify the elements of cancer patients, and found great clinical importance, and. Workshop in May, the first increase in the document Population of CD4 + CD25 + T reg cells at the tumor site in patients with non-small cell lung cancer (34, 35). These studies, more than a third of non-small cell lung cancer has been clearly shown, CD4 + T - TIL CD4 + CD25 + T reg cells can inhibit cell proliferation of self-
(35). More recent studies of normal and cancerous tissues from 46 In addition, patients with NSCLC tumor tissues can not be much greater Foxp3 mRNA expression in normal tissues (77). Is one of the most Foxp3. Specific marker of cell T - Leg features currently available. Expression of Diameter of NSCLC tumors and Foxp3 flexibility is inversely proportional to the study. Further evaluation of the cell T - REG in the peripheral blood of patients
Non-small cell lung cancer (N = 17) and breast cancer (N = 22) in the T cells showed a limousine Significant increase in the blood of patients compared with non-small cell lung cancer Rather than breast cancer (78) in the blood of patients with healthy volunteers (n = 10), and. Their evaluation by flow cytometry in patients with recurrent non-small cell lung cancer and compared with Healthy volunteers and significantly higher proportion of T cells Limousine , CD3 + (47,6% vs. 33,7%, P = 0.02) CD4 + and (71,0% vs. 52.2% since
Cell subsets P T <0.03). Zhang et al also analyzed the peripheral blood Samples from 55 patients with NSCLC receiving paclitaxel-based chemotherapy (79). Paclitaxel is a mitotic inhibitor that is considered a promising tool, Treatment of advanced non-small cell lung cancer. Among the researchers found that lymphocytes Subsidiary, paclitaxel, reducing the size and population of T reg cells selectively Is a subset of effector T cells. The evaluation showed that the mechanism of the subsequent Death receptor Fas (CD95) up-regulation of selectively Induced apoptosis of T cell populations by limousine. On the other hand, the function of T reg cells Significant decrease in the production of cytokines author TH1,
Interleukin-2 and interferon-γ, and expression of activation markers CD44 is a higher CD4, and CD8 + T cell subsets after was intact + Paclitaxel treatment. From these studies the number of lung cancer and other off And research group, reported that the growth of cells in the peripheral CD4 + CD25 + T reg A variety of cancers TIL ball lymphocytes (PBL) (80 - 83). These findings are consistent with studies showing that mice Decline of CD4 + CD25 + T cells can significantly increase the effectiveness limousine Cancer vaccination (84). Together, these data have suggested that T cells - Select a REG They are special non-small cell lung cancer tumors contribute to the immune Microscopic characteristics of the development of non-small cell lung cancer. Wanted Regguseru - but not lung cancer, one of the first studies to link the T Diagnostics and research Curiel and his colleagues 104 patients with ovarian cancer (85) of cells of Foxp3 in CD4 + CD25 + + T reg. When data were available, the tumor cells, T reg has been associated with decreased content Whole (N = 70, P <0001) Survival of groups such as stage and the second (P = 0.0362), The third stage (P = 0,0003) and stage IV (P = 0.0001) groups. Cox proportional hazards Model, a marker of T reg in a higher risk of death after tumor cell Stage, tumor debulking surgery, please check other factors affecting the survival and (P <0.0001). Increased number of T-type combination of the volume, there is a task Reduced the survival rate of ovarian cancer and the sign of the increased risk of death. This group, and T-cell homeostasis of CD4 + CD25 + cells was found to be in contrast Lymph nodes from patients with advanced disease, T - cell REG, preferably home Preferably, store and ovarian tumors and ascites, it is rarely subject Lymph nodes. In addition, the bond adjacent to the cancer cells and tumor Limousine staff CCL22 chemokine-mediated T cell trafficking The volume. This was the first report of functional CCL22 tumor microenvironment Prohibition of CCL22 reduces T reg cells in vivo, the first signs of Human tumors. These data, while the underlying immune to promote the development of new
The strategy is based on the removal of the cancer patients' T cell population limousine, T of a new road - Cell Biology and limousine regulations suggests Trafficking, yet been discovered, is to clarify. 2 (COX - - 2) study shows the cyclooxygenase and prostaglandin metabolites have E2 (PGE2), by promoting T-leg, the immune response of lung cancer prevention Cell activity. Studies have now been shown to enhance the in vitro inhibition of the PGE2 Regulations and pay limo + CD25 + T cell generation and function of human CD4
Phenotype of the number of CD4 + T - CD25 cells (86.87). Inhibition of PGE2-treated cells, the T Limousine Response to anti-CD3 - stimulated lymphocytes when co-cultured cells later
Transwell (86) to separate. Caused by exposure to PGE2-specific T cells Limousine Factor Foxp3 copy numbers of CD4 + CD25 - T cells that are important to the organization, REG cells expressed in CD4 + CD25 + T. Supernatant of COX - 2 overexpression High levels of PGE2 Foxp3 cell lung cancer is the main cause of divorce CD4 + T - CD25 cells. PGE2 up-regulation of both mRNA and protein levels of Foxp3 Promote activities that promote Foxp3 in Jurkat T cells and. Based on the results of the experiment, Limousine, which has the effect of T cells and expression of COX - 2 rate and volume of The activity of CD4 + CD25 + T reg cells has been identified in mouse models of lung cancer. T cells derived from tumor-induced expression of a particular copy limousine COX-2/PGE2 Increase the activity of T cells and factor Foxp3 - (87) a limousine. Use of lymphocyte EP2 EP4 receptor knockout mice in PGE2 - showed that over Foxp3 gene expression was increased in EP2 receptor cells limousine T. Of in vivo, the inhibition of COX - REG T cell activity in lower frequency 2, Foxp3 is attenuated TIL, tumor expression, and at lightweight. T cells or administration of limousine service By PGE2 in mice lacking the COX inhibitor - 2 reversed these effects.
He was known to us and translational research and basic research this and other To understand the role of CD4 + CD25 + T reg cells in the microenvironment of the lung
Combined to indicate that the clinical development of strategies to reduce REG in lung cancer - justified by the results of these suppressor T cells.