Histology of mesothelioma

mesothelioma is frequently tough to diagnose, partially, as a result of it's histologically heterogeneous
and, partially, as a result of in well, differentiated cases,
it should resemble reactive pleural conditions or adenocarcinoma
of lung (fig. 22. 15). four subtypes of mesothelioma
are recognized in the foremost recent who classification, sixty the
epithelial, sarcomatoid, desmoplastic, and biphasic. epithelial
mesothelioma shows a pattern of tumor cell growth that resembles
that of reactive mesothelium other then includes formation
of tubules, acini, papillae, or sheets. these tumors invade normal
adjacent tissues as well as fat and skeletal muscle. fifty
% of mesotheliomas are of this type. 359 sarcomatoid
mesothelioma is composed of malignant spindle cells that
resemble sarcoma other then could specific cks demonstrable in immunohistochemical
tests. this type represents concerning 16% of
mesotheliomas and carries a worse prognosis than the epithelial
type. 370 desmoplastic mesothelioma is defined as a blandappearing
sarcomatoid mesothelioma in that quite 50%
of the tumor consists of hypocellular, dense collagenous stroma
containing slitlike spaces. 371 as a result of its bland appearance, this
histological subtype could be a diagnostic challenge for the trailologist
and could be misinterpreted as a reactive fibrosing method.
the last histological subtype is biphasic mesothelioma,
that contains each epithelial and sarcomatoid components
and accounts for the remaining 34%.