High-throughput mutational analysis finally

the mutations described previously were discovered separately over
several years. recent technical advances have created it possible
to rapidly sequence the genome of separate tumors to supply
a whole mutational profile of all expressed genes. 338
recently, this technological approach has been employed to
evaluate 188 adenocarcinomas for the presence of mutations
in 623 genes with known or potential relationships to cancer.
over 1000 mutations were identified in 163 of the tumors.
mutations were found in twenty six genes at a major frequency.
the four most commonly mutated genes unsurprisingly were
p53, kras, stk11, and egfr. most of the remaining mutations
were purpose mutations and were present in but 10%
of tumors. notably, most tumors had quite one mutation
and the amount of mutations per tumor was significantly
higher in smokers (maximum 49) than in nonsmokers (maximum
5) consistent with a better somewhat of genetic instability
in tumors of smokers. this project identified many new
potential targets for therapeutic intervention that may take
significantly a lot of time to absolutely assess than it took to identify
them. the relatively low frequency of the mutations suggests
that within the future, sequencing of an outsized range of genes will
be needed to establish therapeutic targets which sequencing
of single genes could be replaced by high-throughput global
sequencing of individual tumor genomes.