An 18-year-old female lion (Panthera leo ) was referred to the
Department of Animal Pathology of the University of Turin (Italy). At
necropsy, multiple nodular, 4-20-mm, confluent white firm nodules were
scattered throughout the pleural surfaces of the thoracic wall and of
the lungs. Histological lesions were represented by proliferations of
papillary structures lined by cuboidal basophilic mesothelial cells with
large, oval nuclei and abundant granular eosinophilic cytoplasm.
Immunohistochemistry revealed immunoreactivity for pancytokeratin and
vimentin. None of the cells expressed calretinin antigen.
Asbestos
fibers and asbestos bodies were not detected respectively by light
microscopy and by Scanning Electron Microscope-Energy Dispersive
Spectrometer investigations. On the contrary, chrysotile asbestos were
identified in samples from shelter material. Histological and
immunohistochemical findings were consistent with the diagnosis of an
epithelial malignant mesothelioma. To our best knowledge, this is the
first report of a pleural mesothelioma in a lion.
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Asbestos;
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Microscopy
Studies;
Tumors;
Zoos;
Microscopy
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